Epithelial cell–specific loss of function of Miz1 causes a spontaneous COPD-like phenotype and up-regulates Ace2 expression in mice

Cigarette smoking, the leading cause of chronic obstructive pulmonary disease (COPD), has been implicated as a risk factor for severe disease in patients infected with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Here we show that mice with lung epithelial cell-specific loss of...

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Detalles Bibliográficos
Autores principales: Do-Umehara, Hanh Chi, Chen, Cong, Zhang, Qiao, Misharin, Alexander V., Abdala-Valencia, Hiam, Casalino-Matsuda, S. Marina, Reyfman, Paul A., Anekalla, Kishore R., Gonzalez-Gonzalez, Francisco J., Sala, Marc A., Peng, Chao, Wu, Ping, Wong, Catherine C. L., Kalhan, Ravi, Bharat, Ankit, Perlman, Harris, Ridge, Karen M., Sznajder, Jacob I., Sporn, Peter H. S., Chandel, Navdeep S., Yu, Jindan, Fu, Xiangdong, Petrache, Irina, Tuder, Rubin, Budinger, G. R. Scott, Liu, Jing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2020
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7428331/
https://www.ncbi.nlm.nih.gov/pubmed/32851183
http://dx.doi.org/10.1126/sciadv.abb7238

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7428331/
https://www.ncbi.nlm.nih.gov/pubmed/32851183
http://dx.doi.org/10.1126/sciadv.abb7238

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