Cargando…
Identifying interactive biological pathways associated with reading disability
INTRODUCTION: Past research has suggested that reading disability is a complex disorder involving genetic and environment contributions, as well as gene–gene and gene–environment interaction, but to date little is known about the underlying mechanisms. METHOD: Using the Avon Longitudinal Study of Pa...
Autores principales: | , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7428467/ https://www.ncbi.nlm.nih.gov/pubmed/32596987 http://dx.doi.org/10.1002/brb3.1735 |
_version_ | 1783571079117144064 |
---|---|
author | Lancaster, Hope Sparks Liu, Xiaonan Dinu, Valentin Li, Jing |
author_facet | Lancaster, Hope Sparks Liu, Xiaonan Dinu, Valentin Li, Jing |
author_sort | Lancaster, Hope Sparks |
collection | PubMed |
description | INTRODUCTION: Past research has suggested that reading disability is a complex disorder involving genetic and environment contributions, as well as gene–gene and gene–environment interaction, but to date little is known about the underlying mechanisms. METHOD: Using the Avon Longitudinal Study of Parents and Children, we assessed the contributions of genetic, demographic, and environmental variables on case–control status using machine learning. We investigated the functional interactions between genes using pathway and network analysis. RESULTS: Our results support a systems approach to studying the etiology of reading disability with many genes (e.g., RAPGEF2, KIAA0319, DLC1) and biological pathways (e.g., neuron migration, positive regulation of dendrite regulation, nervous system development) interacting with each other. We found that single nucleotide variants within genes often had opposite effects and that enriched biological pathways were mediated by neuron migration. We also identified behavioral (i.e., receptive language, nonverbal intelligence, and vocabulary), demographic (i.e., mother's highest education), and environmental (i.e., birthweight) factors that influenced case–control status when accounting for genetic information. DISCUSSION: The behavioral and demographic factors were suggested to be protective against reading disability status, while birthweight conveyed risk. We provided supporting evidence that reading disability has a complex biological and environmental etiology and that there may be a shared genetic and neurobiological architecture for reading (dis)ability. |
format | Online Article Text |
id | pubmed-7428467 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-74284672020-08-17 Identifying interactive biological pathways associated with reading disability Lancaster, Hope Sparks Liu, Xiaonan Dinu, Valentin Li, Jing Brain Behav Original Research INTRODUCTION: Past research has suggested that reading disability is a complex disorder involving genetic and environment contributions, as well as gene–gene and gene–environment interaction, but to date little is known about the underlying mechanisms. METHOD: Using the Avon Longitudinal Study of Parents and Children, we assessed the contributions of genetic, demographic, and environmental variables on case–control status using machine learning. We investigated the functional interactions between genes using pathway and network analysis. RESULTS: Our results support a systems approach to studying the etiology of reading disability with many genes (e.g., RAPGEF2, KIAA0319, DLC1) and biological pathways (e.g., neuron migration, positive regulation of dendrite regulation, nervous system development) interacting with each other. We found that single nucleotide variants within genes often had opposite effects and that enriched biological pathways were mediated by neuron migration. We also identified behavioral (i.e., receptive language, nonverbal intelligence, and vocabulary), demographic (i.e., mother's highest education), and environmental (i.e., birthweight) factors that influenced case–control status when accounting for genetic information. DISCUSSION: The behavioral and demographic factors were suggested to be protective against reading disability status, while birthweight conveyed risk. We provided supporting evidence that reading disability has a complex biological and environmental etiology and that there may be a shared genetic and neurobiological architecture for reading (dis)ability. John Wiley and Sons Inc. 2020-06-28 /pmc/articles/PMC7428467/ /pubmed/32596987 http://dx.doi.org/10.1002/brb3.1735 Text en © 2020 The Authors. Brain and Behavior published by Wiley Periodicals LLC. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Research Lancaster, Hope Sparks Liu, Xiaonan Dinu, Valentin Li, Jing Identifying interactive biological pathways associated with reading disability |
title | Identifying interactive biological pathways associated with reading disability |
title_full | Identifying interactive biological pathways associated with reading disability |
title_fullStr | Identifying interactive biological pathways associated with reading disability |
title_full_unstemmed | Identifying interactive biological pathways associated with reading disability |
title_short | Identifying interactive biological pathways associated with reading disability |
title_sort | identifying interactive biological pathways associated with reading disability |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7428467/ https://www.ncbi.nlm.nih.gov/pubmed/32596987 http://dx.doi.org/10.1002/brb3.1735 |
work_keys_str_mv | AT lancasterhopesparks identifyinginteractivebiologicalpathwaysassociatedwithreadingdisability AT liuxiaonan identifyinginteractivebiologicalpathwaysassociatedwithreadingdisability AT dinuvalentin identifyinginteractivebiologicalpathwaysassociatedwithreadingdisability AT lijing identifyinginteractivebiologicalpathwaysassociatedwithreadingdisability |