Nck1, But Not Nck2, Mediates Disturbed Flow‐Induced p21‐Activated Kinase Activation and Endothelial Permeability

BACKGROUND: Alteration in hemodynamic shear stress at atheroprone sites promotes endothelial paracellular pore formation and permeability. The molecular mechanism remains unknown. METHODS AND RESULTS: We show that Nck (noncatalytic region of tyrosine kinase) deletion significantly ameliorates distur...

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Detalles Bibliográficos
Autores principales: Alfaidi, Mabruka, Bhattarai, Umesh, Orr, A. Wayne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7428973/
https://www.ncbi.nlm.nih.gov/pubmed/32468886
http://dx.doi.org/10.1161/JAHA.120.016099

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7428973/
https://www.ncbi.nlm.nih.gov/pubmed/32468886
http://dx.doi.org/10.1161/JAHA.120.016099

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