Blockade of PAR‐1 Signaling Attenuates Cardiac Hypertrophy and Fibrosis in Renin‐Overexpressing Hypertensive Mice

BACKGROUND: Although PAR‐1 (protease‐activated receptor‐1) exerts important functions in the pathophysiology of the cardiovascular system, the role of PAR‐1 signaling in heart failure development remains largely unknown. We tested the hypothesis that PAR‐1 signaling inhibition has protective effects...

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Detalles Bibliográficos
Autores principales: Yokono, Yoshikazu, Hanada, Kenji, Narita, Masato, Tatara, Yota, Kawamura, Yousuke, Miura, Naotake, Kitayama, Kazutaka, Nakata, Masamichi, Nozaka, Masashi, Kato, Tomo, Kudo, Natsumi, Tsushima, Michiko, Toyama, Yuichi, Itoh, Ken, Tomita, Hirofumi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7429042/
https://www.ncbi.nlm.nih.gov/pubmed/32495720
http://dx.doi.org/10.1161/JAHA.119.015616

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7429042/
https://www.ncbi.nlm.nih.gov/pubmed/32495720
http://dx.doi.org/10.1161/JAHA.119.015616

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