Anti‐ORAI1 antibody DS‐2741a, a specific CRAC channel blocker, shows ideal therapeutic profiles for allergic disease via suppression of aberrant T‐cell and mast cell activation

ORAI1 constitutes the pore‐forming subunit of the calcium release‐activated calcium (CRAC) channel, which is responsible for store‐operated calcium entry into lymphocytes. It is known that ORAI1 is essential for the activation of T cells and mast cells and is considered to be a potent therapeutic ta...

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Detalles Bibliográficos
Autores principales: Aki, Anri, Tanaka, Kento, Nagaoka, Nobumi, Kimura, Takako, Baba, Daichi, Onodera, Yoshikuni, Wada, Teiji, Maeda, Hiroaki, Nakanishi, Toshiyuki, Agatsuma, Toshinori, Komai, Tomoaki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7429349/
https://www.ncbi.nlm.nih.gov/pubmed/32821879
http://dx.doi.org/10.1096/fba.2020-00008

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7429349/
https://www.ncbi.nlm.nih.gov/pubmed/32821879
http://dx.doi.org/10.1096/fba.2020-00008

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