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DiMSum: an error model and pipeline for analyzing deep mutational scanning data and diagnosing common experimental pathologies
Deep mutational scanning (DMS) enables multiplexed measurement of the effects of thousands of variants of proteins, RNAs, and regulatory elements. Here, we present a customizable pipeline, DiMSum, that represents an end-to-end solution for obtaining variant fitness and error estimates from raw seque...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7429474/ https://www.ncbi.nlm.nih.gov/pubmed/32799905 http://dx.doi.org/10.1186/s13059-020-02091-3 |