Signalling, trafficking and glucoregulatory properties of glucagon‐like peptide‐1 receptor agonists exendin‐4 and lixisenatide

BACKGROUND AND PURPOSE: Amino acid substitutions at the N‐termini of glucagon‐like peptide‐1 (GLP‐1) receptor agonist peptides result in distinct patterns of intracellular signalling, sub‐cellular trafficking and efficacy in vivo. Here, we to determine whether sequence differences at the ligand C‐te...

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Detalles Bibliográficos
Autores principales: Pickford, Philip, Lucey, Maria, Fang, Zijian, Bitsi, Stavroula, de la Serna, Jorge Bernardino, Broichhagen, Johannes, Hodson, David J., Minnion, James, Rutter, Guy A., Bloom, Stephen R., Tomas, Alejandra, Jones, Ben
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Research Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7429481/
https://www.ncbi.nlm.nih.gov/pubmed/32436216
http://dx.doi.org/10.1111/bph.15134

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7429481/
https://www.ncbi.nlm.nih.gov/pubmed/32436216
http://dx.doi.org/10.1111/bph.15134

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