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6‐Hydroxydopamine lesion and levodopa treatment modify the effect of buspirone in the substantia nigra pars reticulata

BACKGROUND AND PURPOSE: l‐DOPA‐induced dyskinesia (LID) is considered a major complication in the treatment of Parkinson's disease (PD). Buspirone (5‐HT(1A) partial agonist) have shown promising results in the treatment of PD and LID, however no 5‐HT‐based treatment has been approved in PD. The...

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Detalles Bibliográficos
Autores principales: Vegas‐Suárez, Sergio, Pisanò, Clarissa Anna, Requejo, Catalina, Bengoetxea, Harkaitz, Lafuente, Jose Vicente, Morari, Michele, Miguelez, Cristina, Ugedo, Luisa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7429490/
https://www.ncbi.nlm.nih.gov/pubmed/32464686
http://dx.doi.org/10.1111/bph.15145