Chemogenomic screening identifies the Hsp70 co-chaperone DNAJA1 as a hub for anticancer drug resistance

Heat shock protein 70 (Hsp70) is an important molecular chaperone that regulates oncoprotein stability and tumorigenesis. However, attempts to develop anti-chaperone drugs targeting molecules such as Hsp70 have been hampered by toxicity issues. Hsp70 is regulated by a suite of co-chaperone molecules...

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Detalles Bibliográficos
Autores principales: Nitika, Blackman, Jacob S., Knighton, Laura E., Takakuwa, Jade E., Calderwood, Stuart K., Truman, Andrew W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7429498/
https://www.ncbi.nlm.nih.gov/pubmed/32796891
http://dx.doi.org/10.1038/s41598-020-70764-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7429498/
https://www.ncbi.nlm.nih.gov/pubmed/32796891
http://dx.doi.org/10.1038/s41598-020-70764-x

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