Distinct promoter methylation patterns of LKB1 in the hamartomatous polyps of Peutz-Jeghers syndrome and its potential in gastrointestinal malignancy prediction

BACKGROUND: Peutz-Jeghers Syndrome (PJS) is known as a rare inherited polyposis due to the malfunction of serine/threonine kinase gene LKB1. However, not all of PJS patients carry LKB1 germline mutation. Previous researches have observed the elevated DNA methylation level in PJS polyps. Nevertheless...

Descripción completa

Detalles Bibliográficos
Autores principales: Li, Teng, Lin, Wensheng, Zhao, Yilei, Zhu, Jianping, Sun, Tao, Ren, Li
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7429683/
https://www.ncbi.nlm.nih.gov/pubmed/32799895
http://dx.doi.org/10.1186/s13023-020-01502-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7429683/
https://www.ncbi.nlm.nih.gov/pubmed/32799895
http://dx.doi.org/10.1186/s13023-020-01502-9

Ejemplares similares