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Distinct promoter methylation patterns of LKB1 in the hamartomatous polyps of Peutz-Jeghers syndrome and its potential in gastrointestinal malignancy prediction

BACKGROUND: Peutz-Jeghers Syndrome (PJS) is known as a rare inherited polyposis due to the malfunction of serine/threonine kinase gene LKB1. However, not all of PJS patients carry LKB1 germline mutation. Previous researches have observed the elevated DNA methylation level in PJS polyps. Nevertheless...

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Detalles Bibliográficos
Autores principales:	Li, Teng, Lin, Wensheng, Zhao, Yilei, Zhu, Jianping, Sun, Tao, Ren, Li
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2020
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7429683/ https://www.ncbi.nlm.nih.gov/pubmed/32799895 http://dx.doi.org/10.1186/s13023-020-01502-9

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