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Amino acid-dependent control of mTORC1 signaling: a variety of regulatory modes

The mechanistic target of rapamycin complex 1 (mTORC1) is an essential regulator of cell growth and metabolism through the modulation of protein and lipid synthesis, lysosome biogenesis, and autophagy. The activity of mTORC1 is dynamically regulated by several environmental cues, including amino aci...

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Autores principales: Takahara, Terunao, Amemiya, Yuna, Sugiyama, Risa, Maki, Masatoshi, Shibata, Hideki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7429791/
https://www.ncbi.nlm.nih.gov/pubmed/32799865
http://dx.doi.org/10.1186/s12929-020-00679-2
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author Takahara, Terunao
Amemiya, Yuna
Sugiyama, Risa
Maki, Masatoshi
Shibata, Hideki
author_facet Takahara, Terunao
Amemiya, Yuna
Sugiyama, Risa
Maki, Masatoshi
Shibata, Hideki
author_sort Takahara, Terunao
collection PubMed
description The mechanistic target of rapamycin complex 1 (mTORC1) is an essential regulator of cell growth and metabolism through the modulation of protein and lipid synthesis, lysosome biogenesis, and autophagy. The activity of mTORC1 is dynamically regulated by several environmental cues, including amino acid availability, growth factors, energy levels, and stresses, to coordinate cellular status with environmental conditions. Dysregulation of mTORC1 activity is closely associated with various diseases, including diabetes, cancer, and neurodegenerative disorders. The discovery of Rag GTPases has greatly expanded our understanding of the regulation of mTORC1 activity by amino acids, especially leucine and arginine. In addition to Rag GTPases, other factors that also contribute to the modulation of mTORC1 activity have been identified. In this review, we discuss the mechanisms of regulation of mTORC1 activity by particular amino acids.
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spelling pubmed-74297912020-08-18 Amino acid-dependent control of mTORC1 signaling: a variety of regulatory modes Takahara, Terunao Amemiya, Yuna Sugiyama, Risa Maki, Masatoshi Shibata, Hideki J Biomed Sci Review The mechanistic target of rapamycin complex 1 (mTORC1) is an essential regulator of cell growth and metabolism through the modulation of protein and lipid synthesis, lysosome biogenesis, and autophagy. The activity of mTORC1 is dynamically regulated by several environmental cues, including amino acid availability, growth factors, energy levels, and stresses, to coordinate cellular status with environmental conditions. Dysregulation of mTORC1 activity is closely associated with various diseases, including diabetes, cancer, and neurodegenerative disorders. The discovery of Rag GTPases has greatly expanded our understanding of the regulation of mTORC1 activity by amino acids, especially leucine and arginine. In addition to Rag GTPases, other factors that also contribute to the modulation of mTORC1 activity have been identified. In this review, we discuss the mechanisms of regulation of mTORC1 activity by particular amino acids. BioMed Central 2020-08-17 /pmc/articles/PMC7429791/ /pubmed/32799865 http://dx.doi.org/10.1186/s12929-020-00679-2 Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Takahara, Terunao
Amemiya, Yuna
Sugiyama, Risa
Maki, Masatoshi
Shibata, Hideki
Amino acid-dependent control of mTORC1 signaling: a variety of regulatory modes
title Amino acid-dependent control of mTORC1 signaling: a variety of regulatory modes
title_full Amino acid-dependent control of mTORC1 signaling: a variety of regulatory modes
title_fullStr Amino acid-dependent control of mTORC1 signaling: a variety of regulatory modes
title_full_unstemmed Amino acid-dependent control of mTORC1 signaling: a variety of regulatory modes
title_short Amino acid-dependent control of mTORC1 signaling: a variety of regulatory modes
title_sort amino acid-dependent control of mtorc1 signaling: a variety of regulatory modes
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7429791/
https://www.ncbi.nlm.nih.gov/pubmed/32799865
http://dx.doi.org/10.1186/s12929-020-00679-2
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