Scavenging of reactive dicarbonyls with 2-hydroxybenzylamine reduces atherosclerosis in hypercholesterolemic Ldlr(−/−) mice

Lipid peroxidation generates reactive dicarbonyls including isolevuglandins (IsoLGs) and malondialdehyde (MDA) that covalently modify proteins. Humans with familial hypercholesterolemia (FH) have increased lipoprotein dicarbonyl adducts and dysfunctional HDL. We investigate the impact of the dicarbo...

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Detalles Bibliográficos
Autores principales: Tao, Huan, Huang, Jiansheng, Yancey, Patricia G., Yermalitsky, Valery, Blakemore, John L., Zhang, Youmin, Ding, Lei, Zagol-Ikapitte, Irene, Ye, Fei, Amarnath, Venkataraman, Boutaud, Olivier, Oates, John A., Roberts, L. Jackson, Davies, Sean S., Linton, MacRae F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7429830/
https://www.ncbi.nlm.nih.gov/pubmed/32796843
http://dx.doi.org/10.1038/s41467-020-17915-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7429830/
https://www.ncbi.nlm.nih.gov/pubmed/32796843
http://dx.doi.org/10.1038/s41467-020-17915-w

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