Chemically induced mutations in a MutaMouse reporter gene inform mechanisms underlying human cancer mutational signatures

Transgenic rodent (TGR) models use bacterial reporter genes to quantify in vivo mutagenesis. Pairing TGR assays with next-generation sequencing (NGS) enables comprehensive mutation pattern analysis to inform mutational mechanisms. We used this approach to identify 2751 independent lacZ mutations in...

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Detalles Bibliográficos
Autores principales: Beal, Marc A., Meier, Matthew J., LeBlanc, Danielle P., Maurice, Clotilde, O’Brien, Jason M., Yauk, Carole L., Marchetti, Francesco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7429849/
https://www.ncbi.nlm.nih.gov/pubmed/32796912
http://dx.doi.org/10.1038/s42003-020-01174-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7429849/
https://www.ncbi.nlm.nih.gov/pubmed/32796912
http://dx.doi.org/10.1038/s42003-020-01174-y

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