Yap haploinsufficiency leads to Müller cell dysfunction and late-onset cone dystrophy

Hippo signalling regulates eye growth during embryogenesis through its effectors YAP and TAZ. Taking advantage of a Yap heterozygous mouse line, we here sought to examine its function in adult neural retina, where YAP expression is restricted to Müller glia. We first discovered an unexpected tempora...

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Detalles Bibliográficos
Autores principales: Masson, Christel, García-García, Diana, Bitard, Juliette, Grellier, Élodie-Kim, Roger, Jérôme E., Perron, Muriel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7429854/
https://www.ncbi.nlm.nih.gov/pubmed/32801350
http://dx.doi.org/10.1038/s41419-020-02860-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7429854/
https://www.ncbi.nlm.nih.gov/pubmed/32801350
http://dx.doi.org/10.1038/s41419-020-02860-9

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