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Yap haploinsufficiency leads to Müller cell dysfunction and late-onset cone dystrophy
Hippo signalling regulates eye growth during embryogenesis through its effectors YAP and TAZ. Taking advantage of a Yap heterozygous mouse line, we here sought to examine its function in adult neural retina, where YAP expression is restricted to Müller glia. We first discovered an unexpected tempora...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7429854/ https://www.ncbi.nlm.nih.gov/pubmed/32801350 http://dx.doi.org/10.1038/s41419-020-02860-9 |