53BP1 loss rescues embryonic lethality but not genomic instability of BRCA1 total knockout mice

BRCA1 is critical for DNA double-strand break (DSB) repair by homologous recombination (HR). BRCA1 deficient mice are embryonic lethal. Previous studies have shown that 53BP1 knockout (KO) rescues embryonic lethality of BRCA1 hypomorphic mutant mice by restoring HR. Here, we show that 53BP1 KO can p...

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Detalles Bibliográficos
Autores principales: Chen, Jiyuan, Li, Peng, Song, Licun, Bai, Long, Huen, Michael S. Y., Liu, Yidan, Lu, Lin-Yu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7429965/
https://www.ncbi.nlm.nih.gov/pubmed/32139898
http://dx.doi.org/10.1038/s41418-020-0521-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7429965/
https://www.ncbi.nlm.nih.gov/pubmed/32139898
http://dx.doi.org/10.1038/s41418-020-0521-4

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