Methylene blue inhibits nucleation and elongation of SOD1 amyloid fibrils

Protein aggregation into highly-structured amyloid fibrils is linked to several neurodegenerative diseases. Such fibril formation by superoxide dismutase I (SOD1) is considered to be related to amyotrophic lateral sclerosis, a late-onset and fatal disorder. Despite much effort and the discovery of n...

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Detalles Bibliográficos
Autores principales: Musteikyte, Greta, Ziaunys, Mantas, Smirnovas, Vytautas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: PeerJ Inc. 2020
Materias:
Biochemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7430317/
https://www.ncbi.nlm.nih.gov/pubmed/32864220
http://dx.doi.org/10.7717/peerj.9719

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7430317/
https://www.ncbi.nlm.nih.gov/pubmed/32864220
http://dx.doi.org/10.7717/peerj.9719

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