Methylene blue inhibits nucleation and elongation of SOD1 amyloid fibrils

Protein aggregation into highly-structured amyloid fibrils is linked to several neurodegenerative diseases. Such fibril formation by superoxide dismutase I (SOD1) is considered to be related to amyotrophic lateral sclerosis, a late-onset and fatal disorder. Despite much effort and the discovery of n...

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Autores principales: Musteikyte, Greta, Ziaunys, Mantas, Smirnovas, Vytautas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: PeerJ Inc. 2020
Materias:
Biochemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7430317/
https://www.ncbi.nlm.nih.gov/pubmed/32864220
http://dx.doi.org/10.7717/peerj.9719
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author Musteikyte, Greta
Ziaunys, Mantas
Smirnovas, Vytautas
author_facet Musteikyte, Greta
Ziaunys, Mantas
Smirnovas, Vytautas
author_sort Musteikyte, Greta
collection PubMed
description Protein aggregation into highly-structured amyloid fibrils is linked to several neurodegenerative diseases. Such fibril formation by superoxide dismutase I (SOD1) is considered to be related to amyotrophic lateral sclerosis, a late-onset and fatal disorder. Despite much effort and the discovery of numerous anti-amyloid compounds, no effective cure or treatment is currently available. Methylene blue (MB), a phenothiazine dye, has been shown to modulate the aggregation of multiple amyloidogenic proteins. In this work we show its ability to inhibit both the spontaneous amyloid aggregation of SOD1 as well as elongation of preformed fibrils.
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spelling pubmed-74303172020-08-27 Methylene blue inhibits nucleation and elongation of SOD1 amyloid fibrils Musteikyte, Greta Ziaunys, Mantas Smirnovas, Vytautas PeerJ Biochemistry Protein aggregation into highly-structured amyloid fibrils is linked to several neurodegenerative diseases. Such fibril formation by superoxide dismutase I (SOD1) is considered to be related to amyotrophic lateral sclerosis, a late-onset and fatal disorder. Despite much effort and the discovery of numerous anti-amyloid compounds, no effective cure or treatment is currently available. Methylene blue (MB), a phenothiazine dye, has been shown to modulate the aggregation of multiple amyloidogenic proteins. In this work we show its ability to inhibit both the spontaneous amyloid aggregation of SOD1 as well as elongation of preformed fibrils. PeerJ Inc. 2020-08-14 /pmc/articles/PMC7430317/ /pubmed/32864220 http://dx.doi.org/10.7717/peerj.9719 Text en ©2020 Musteikyte et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, reproduction and adaptation in any medium and for any purpose provided that it is properly attributed. For attribution, the original author(s), title, publication source (PeerJ) and either DOI or URL of the article must be cited.
spellingShingle Biochemistry
Musteikyte, Greta
Ziaunys, Mantas
Smirnovas, Vytautas
Methylene blue inhibits nucleation and elongation of SOD1 amyloid fibrils
title Methylene blue inhibits nucleation and elongation of SOD1 amyloid fibrils
title_full Methylene blue inhibits nucleation and elongation of SOD1 amyloid fibrils
title_fullStr Methylene blue inhibits nucleation and elongation of SOD1 amyloid fibrils
title_full_unstemmed Methylene blue inhibits nucleation and elongation of SOD1 amyloid fibrils
title_short Methylene blue inhibits nucleation and elongation of SOD1 amyloid fibrils
title_sort methylene blue inhibits nucleation and elongation of sod1 amyloid fibrils
topic Biochemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7430317/
https://www.ncbi.nlm.nih.gov/pubmed/32864220
http://dx.doi.org/10.7717/peerj.9719
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AT smirnovasvytautas methyleneblueinhibitsnucleationandelongationofsod1amyloidfibrils

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