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Ureidothiophene inhibits interaction of bacterial RNA polymerase with –10 promotor element

Bacterial RNA polymerase is a potent target for antibiotics, which utilize a plethora of different modes of action, some of which are still not fully understood. Ureidothiophene (Urd) was found in a screen of a library of chemical compounds for ability to inhibit bacterial transcription. The mechani...

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Detalles Bibliográficos
Autores principales: Harbottle, John, Zenkin, Nikolay
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7430646/
https://www.ncbi.nlm.nih.gov/pubmed/32652039
http://dx.doi.org/10.1093/nar/gkaa591