Human GTPBP5 (MTG2) fuels mitoribosome large subunit maturation by facilitating 16S rRNA methylation

Biogenesis of mammalian mitochondrial ribosomes (mitoribosomes) involves several conserved small GTPases. Here, we report that the Obg family protein GTPBP5 or MTG2 is a mitochondrial protein whose absence in a TALEN-induced HEK293T knockout (KO) cell line leads to severely decreased levels of the 5...

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Detalles Bibliográficos
Autores principales: Maiti, Priyanka, Antonicka, Hana, Gingras, Anne-Claude, Shoubridge, Eric A, Barrientos, Antoni
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Molecular Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7430652/
https://www.ncbi.nlm.nih.gov/pubmed/32652011
http://dx.doi.org/10.1093/nar/gkaa592

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7430652/
https://www.ncbi.nlm.nih.gov/pubmed/32652011
http://dx.doi.org/10.1093/nar/gkaa592

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