A CRAF/glutathione-S-transferase P1 complex sustains autocrine growth of cancers with KRAS and BRAF mutations

The Ras/RAF/MEK/ERK pathway is an essential signaling cascade for various refractory cancers, such as those with mutant KRAS (mKRAS) and BRAF (mBRAF). However, there are unsolved ambiguities underlying mechanisms for this growth signaling thereby creating therapeutic complications. This study shows...

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Detalles Bibliográficos
Autores principales: Niitsu, Yoshiro, Sato, Yasushi, Takanashi, Kunihiro, Hayashi, Tsuyoshi, Kubo-Birukawa, Naoko, Shimizu, Fumiko, Fujitani, Naoki, Shimoyama, Rai, Kukitsu, Takehiro, Kurata, Wataru, Tashiro, Yasuyuki, Listowsky, Irving
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2020
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7430992/
https://www.ncbi.nlm.nih.gov/pubmed/32719131
http://dx.doi.org/10.1073/pnas.2000361117

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7430992/
https://www.ncbi.nlm.nih.gov/pubmed/32719131
http://dx.doi.org/10.1073/pnas.2000361117

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