Absence of cGAS-mediated type I IFN responses in HIV-1–infected T cells

The DNA sensor cGAS catalyzes the production of the cyclic dinucleotide cGAMP, resulting in type I interferon responses. We addressed the functionality of cGAS-mediated DNA sensing in human and murine T cells. Activated primary CD4(+) T cells expressed cGAS and responded to plasmid DNA by upregulati...

Descripción completa

Detalles Bibliográficos
Autores principales: Elsner, Carina, Ponnurangam, Aparna, Kazmierski, Julia, Zillinger, Thomas, Jansen, Jenny, Todt, Daniel, Döhner, Katinka, Xu, Shuting, Ducroux, Aurélie, Kriedemann, Nils, Malassa, Angelina, Larsen, Pia-Katharina, Hartmann, Gunther, Barchet, Winfried, Steinmann, Eike, Kalinke, Ulrich, Sodeik, Beate, Goffinet, Christine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2020
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7431009/
https://www.ncbi.nlm.nih.gov/pubmed/32709741
http://dx.doi.org/10.1073/pnas.2002481117

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7431009/
https://www.ncbi.nlm.nih.gov/pubmed/32709741
http://dx.doi.org/10.1073/pnas.2002481117

Ejemplares similares