FEN1 endonuclease as a therapeutic target for human cancers with defects in homologous recombination

Synthetic lethality strategies for cancer therapy exploit cancer-specific genetic defects to identify targets that are uniquely essential to the survival of tumor cells. Here we show RAD27/FEN1, which encodes flap endonuclease 1 (FEN1), a structure-specific nuclease with roles in DNA replication and...

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Detalles Bibliográficos
Autores principales: Guo, Elaine, Ishii, Yuki, Mueller, James, Srivatsan, Anjana, Gahman, Timothy, Putnam, Christopher D., Wang, Jean Y. J., Kolodner, Richard D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2020
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7431096/
https://www.ncbi.nlm.nih.gov/pubmed/32719125
http://dx.doi.org/10.1073/pnas.2009237117

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7431096/
https://www.ncbi.nlm.nih.gov/pubmed/32719125
http://dx.doi.org/10.1073/pnas.2009237117

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