Isolated Adrenocorticotropic Hormone Deficiency Secondary to Chronic Opiate Use
Although opiate use can result in various endocrine disorders, isolated adrenocorticotropic hormone (ACTH) deficiency resulting in secondary adrenal insufficiency remains uncommon. We present a case of a 54-year-old woman with a history of chronic opiate use who presented with a four-month history o...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Cureus
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7431316/ https://www.ncbi.nlm.nih.gov/pubmed/32821615 http://dx.doi.org/10.7759/cureus.9270 |
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author | Raj, Rishi Jacob, Aasems Elshimy, Ghada Smith, Jackson |
author_facet | Raj, Rishi Jacob, Aasems Elshimy, Ghada Smith, Jackson |
author_sort | Raj, Rishi |
collection | PubMed |
description | Although opiate use can result in various endocrine disorders, isolated adrenocorticotropic hormone (ACTH) deficiency resulting in secondary adrenal insufficiency remains uncommon. We present a case of a 54-year-old woman with a history of chronic opiate use who presented with a four-month history of worsening fatigue and syncopal episodes. Laboratory workup revealed a low ACTH with low baseline cortisol and normal levels of rest of the anterior pituitary hormones. The imaging study did not reveal any pituitary abnormality. The patient was diagnosed with opiate-induced isolated ACTH deficiency. Her symptoms improved after treatment with hydrocortisone. This case would further improve clinician's awareness towards opiate-induced endocrinopathies, including isolated ACTH deficiency, which can present with nonspecific signs and symptoms, creating a diagnostic challenge. |
format | Online Article Text |
id | pubmed-7431316 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Cureus |
record_format | MEDLINE/PubMed |
spelling | pubmed-74313162020-08-18 Isolated Adrenocorticotropic Hormone Deficiency Secondary to Chronic Opiate Use Raj, Rishi Jacob, Aasems Elshimy, Ghada Smith, Jackson Cureus Endocrinology/Diabetes/Metabolism Although opiate use can result in various endocrine disorders, isolated adrenocorticotropic hormone (ACTH) deficiency resulting in secondary adrenal insufficiency remains uncommon. We present a case of a 54-year-old woman with a history of chronic opiate use who presented with a four-month history of worsening fatigue and syncopal episodes. Laboratory workup revealed a low ACTH with low baseline cortisol and normal levels of rest of the anterior pituitary hormones. The imaging study did not reveal any pituitary abnormality. The patient was diagnosed with opiate-induced isolated ACTH deficiency. Her symptoms improved after treatment with hydrocortisone. This case would further improve clinician's awareness towards opiate-induced endocrinopathies, including isolated ACTH deficiency, which can present with nonspecific signs and symptoms, creating a diagnostic challenge. Cureus 2020-07-19 /pmc/articles/PMC7431316/ /pubmed/32821615 http://dx.doi.org/10.7759/cureus.9270 Text en Copyright © 2020, Raj et al. http://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Endocrinology/Diabetes/Metabolism Raj, Rishi Jacob, Aasems Elshimy, Ghada Smith, Jackson Isolated Adrenocorticotropic Hormone Deficiency Secondary to Chronic Opiate Use |
title | Isolated Adrenocorticotropic Hormone Deficiency Secondary to Chronic Opiate Use |
title_full | Isolated Adrenocorticotropic Hormone Deficiency Secondary to Chronic Opiate Use |
title_fullStr | Isolated Adrenocorticotropic Hormone Deficiency Secondary to Chronic Opiate Use |
title_full_unstemmed | Isolated Adrenocorticotropic Hormone Deficiency Secondary to Chronic Opiate Use |
title_short | Isolated Adrenocorticotropic Hormone Deficiency Secondary to Chronic Opiate Use |
title_sort | isolated adrenocorticotropic hormone deficiency secondary to chronic opiate use |
topic | Endocrinology/Diabetes/Metabolism |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7431316/ https://www.ncbi.nlm.nih.gov/pubmed/32821615 http://dx.doi.org/10.7759/cureus.9270 |
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