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Human NMD ensues independently of stable ribosome stalling

Nonsense-mediated mRNA decay (NMD) is a translation-dependent RNA degradation pathway that is important for the elimination of faulty, and the regulation of normal, mRNAs. The molecular details of the early steps in NMD are not fully understood but previous work suggests that NMD activation occurs a...

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Detalles Bibliográficos
Autores principales: Karousis, Evangelos D., Gurzeler, Lukas-Adrian, Annibaldis, Giuditta, Dreos, René, Mühlemann, Oliver
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7431590/
https://www.ncbi.nlm.nih.gov/pubmed/32807779
http://dx.doi.org/10.1038/s41467-020-17974-z