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Syntheses of spliceostatins and thailanstatins: a review

The spliceostatins/thailanstatins are a family of linear peptides/polyketides that inhibit pre-mRNA splicing, and as such act as potent cytotoxic compounds. These compounds generally contain 9 stereocenters spread over a common (2Z,4S)-4-acetoxy-2-butenamide fragment, an (all-cis)-2,3,5,6-tetrasubst...

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Detalles Bibliográficos
Autor principal: Donaldson, William A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Beilstein-Institut 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7431757/
https://www.ncbi.nlm.nih.gov/pubmed/32831956
http://dx.doi.org/10.3762/bjoc.16.166

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