Comprehensive Model for Epidermal Growth Factor Receptor Ligand Binding Involving Conformational States of the Extracellular and the Kinase Domains

The epidermal growth factor (EGF) receptor (EGFR) undergoes ligand-dependent dimerization to initiate transmembrane signaling. Although crystallographic structures of the extracellular and kinase domains are available, ligand binding has not been quantitatively analyzed taking the influence of both...

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Detalles Bibliográficos
Autores principales: Hajdu, Tímea, Váradi, Tímea, Rebenku, István, Kovács, Tamás, Szöllösi, János, Nagy, Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Cell and Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7431817/
https://www.ncbi.nlm.nih.gov/pubmed/32850868
http://dx.doi.org/10.3389/fcell.2020.00776

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7431817/
https://www.ncbi.nlm.nih.gov/pubmed/32850868
http://dx.doi.org/10.3389/fcell.2020.00776

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