Targeting RAS‐converting enzyme 1 overcomes senescence and improves progeria‐like phenotypes of ZMPSTE24 deficiency

Several progeroid disorders are caused by deficiency in the endoprotease ZMPSTE24 which leads to accumulation of prelamin A at the nuclear envelope. ZMPSTE24 cleaves prelamin A twice: at the third carboxyl‐terminal amino acid following farnesylation of a –CSIM motif; and 15 residues upstream to prod...

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Detalles Bibliográficos
Autores principales: Yao, Haidong, Chen, Xue, Kashif, Muhammad, Wang, Ting, Ibrahim, Mohamed X., Tüksammel, Elin, Revêchon, Gwladys, Eriksson, Maria, Wiel, Clotilde, Bergo, Martin O.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Short Take
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7431821/
https://www.ncbi.nlm.nih.gov/pubmed/32910507
http://dx.doi.org/10.1111/acel.13200

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7431821/
https://www.ncbi.nlm.nih.gov/pubmed/32910507
http://dx.doi.org/10.1111/acel.13200

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