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Targeting RAS‐converting enzyme 1 overcomes senescence and improves progeria‐like phenotypes of ZMPSTE24 deficiency
Several progeroid disorders are caused by deficiency in the endoprotease ZMPSTE24 which leads to accumulation of prelamin A at the nuclear envelope. ZMPSTE24 cleaves prelamin A twice: at the third carboxyl‐terminal amino acid following farnesylation of a –CSIM motif; and 15 residues upstream to prod...
Autores principales: | Yao, Haidong, Chen, Xue, Kashif, Muhammad, Wang, Ting, Ibrahim, Mohamed X., Tüksammel, Elin, Revêchon, Gwladys, Eriksson, Maria, Wiel, Clotilde, Bergo, Martin O. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7431821/ https://www.ncbi.nlm.nih.gov/pubmed/32910507 http://dx.doi.org/10.1111/acel.13200 |
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