Strength of immune selection in tumors varies with sex and age

Individual MHC genotype constrains the mutational landscape during tumorigenesis. Immune checkpoint inhibition reactivates immunity against tumors that escaped immune surveillance in approximately 30% of cases. Recent studies demonstrated poorer response rates in female and younger patients. Althoug...

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Detalles Bibliográficos
Autores principales: Castro, Andrea, Pyke, Rachel Marty, Zhang, Xinlian, Thompson, Wesley Kurt, Day, Chi-Ping, Alexandrov, Ludmil B., Zanetti, Maurizio, Carter, Hannah
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7431859/
https://www.ncbi.nlm.nih.gov/pubmed/32807809
http://dx.doi.org/10.1038/s41467-020-17981-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7431859/
https://www.ncbi.nlm.nih.gov/pubmed/32807809
http://dx.doi.org/10.1038/s41467-020-17981-0

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