Cytoplasmic Citrate Flux Modulates the Immune Stimulatory NKG2D Ligand MICA in Cancer Cells

Immune surveillance of cancer cells is facilitated by the Natural Killer Group 2D (NKG2D) receptor expressed by different lymphocyte subsets. It recognizes NKG2D ligands that are rarely expressed on healthy cells, but upregulated by tumorigenesis, presenting a target for immunological clearance. The...

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Detalles Bibliográficos
Autores principales: Møller, Sofie H., Mellergaard, Maiken, Madsen, Mikkel, Bermejo, Amaia V., Jepsen, Stine D., Hansen, Marie H., Høgh, Rikke I., Aldana, Blanca I., Desler, Claus, Rasmussen, Lene Juel, Sustarsic, Elahu G., Gerhart-Hines, Zachary, Daskalaki, Evangelia, Wheelock, Craig E., Hiron, Thomas K., Lin, Da, O’Callaghan, Christopher A., Wandall, Hans H., Andresen, Lars, Skov, Søren
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7431954/
https://www.ncbi.nlm.nih.gov/pubmed/32849657
http://dx.doi.org/10.3389/fimmu.2020.01968

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7431954/
https://www.ncbi.nlm.nih.gov/pubmed/32849657
http://dx.doi.org/10.3389/fimmu.2020.01968

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