Cargando…

Predicting Carcinogenic Mechanisms of Non-Genotoxic Carcinogens via Combined Analysis of Global DNA Methylation and In Vitro Cell Transformation

An in vitro cell transformation assay (CTA) is useful for the detection of non-genotoxic carcinogens (NGTXCs); however, it does not provide information on their modes of action. In this study, to pursue a mechanism-based approach in the risk assessment of NGTXCs, we aimed to develop an integrated st...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hwang, Sung-Hee, Yeom, Hojin, Han, Byeal-I, Ham, Byung-Joo, Lee, Yong-Moon, Han, Mi-Ryung, Lee, Michael
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7432388/ https://www.ncbi.nlm.nih.gov/pubmed/32751172 http://dx.doi.org/10.3390/ijms21155387

Ejemplares similares

Are genotoxic carcinogens more potent than nongenotoxic carcinogens?
por: Parodi, S, et al.
Publicado: (1991)

Thresholds of Genotoxic and Non-Genotoxic Carcinogens
por: Nohmi, Takehiko
Publicado: (2018)

Quantitative Approaches to Assess Key Carcinogenic Events of Genotoxic Carcinogens
por: Fukushima, Shoji, et al.
Publicado: (2018)

Differential Sensitivity of Wild-Type and BRAF-Mutated Cells to Combined BRAF and Autophagy Inhibition
por: Yeom, Hojin, et al.
Publicado: (2021)

A novel, integrated in vitro carcinogenicity test to identify genotoxic and non-genotoxic carcinogens using human lymphoblastoid cells
por: Wilde, Eleanor C., et al.
Publicado: (2017)

Mequindox Induced Genotoxicity and Carcinogenicity in Mice
por: Liu, Qianying, et al.
Publicado: (2018)

Thirdhand smoke: Genotoxicity and carcinogenic potential
por: Hang, Bo, et al.
Publicado: (2019)

Investigating the Different Mechanisms of Genotoxic and Non-Genotoxic Carcinogens by a Gene Set Analysis
por: Lee, Won Jun, et al.
Publicado: (2014)

Anomalous nonidentity between Salmonella genotoxicants and rodent carcinogens: nongenotoxic carcinogens and genotoxic noncarcinogens.
por: Yoshikawa, K
Publicado: (1996)

Databases of genotoxicity and carcinogenicity and their usefulness for hazard evaluation.
Publicado: (1991)

Corrigendum: Mequindox Induced Genotoxicity and Carcinogenicity in Mice
por: Liu, Qianying, et al.
Publicado: (2018)

Short-term in vivo testing to discriminate genotoxic carcinogens from non-genotoxic carcinogens and non-carcinogens using next-generation RNA sequencing, DNA microarray, and qPCR
por: Furihata, Chie, et al.
Publicado: (2023)

Data selection and treatment of chemicals tested for genotoxicity and carcinogenicity.
por: Loprieno, N, et al.
Publicado: (1991)

A Mode-of-Action Approach for the Identification of Genotoxic Carcinogens
por: Hernández, Lya G., et al.
Publicado: (2013)

Genotoxicity and carcinogenicity of cobalt-, nickel- and copper-based nanoparticles
por: MAGAYE, RUTH, et al.
Publicado: (2012)

Mode of action-based risk assessment of genotoxic carcinogens
por: Hartwig, Andrea, et al.
Publicado: (2020)

Threshold of Toxicological Concern—An Update for Non-Genotoxic Carcinogens
por: Batke, Monika, et al.
Publicado: (2021)

Comparison of Reversibility of Rat Forestomach Lesions Induced by Genotoxic and Non‐genotoxic Carcinogens
por: Kagawa, Masataka, et al.
Publicado: (1993)

Role of genotoxic and nongenotoxic effects in multistage carcinogenicity of aromatic amines.
por: Neumann, H G, et al.
Publicado: (1990)

Analysis and comparison of information and data recorded in carcinogenicity and genotoxicity databases.
por: Romano, P, et al.
Publicado: (1991)

Mathematical models for exploring different aspects of genotoxicity and carcinogenicity databases.
por: Benigni, R, et al.
Publicado: (1991)

Is Senna Laxative Use Associated to Cathartic Colon, Genotoxicity, or Carcinogenicity?
por: Morales, M. A., et al.
Publicado: (2009)

QSAR ligand dataset for modelling mutagenicity, genotoxicity, and rodent carcinogenicity
por: Guan, Davy, et al.
Publicado: (2018)

Recruitment of Normal Stem Cells to an Oncogenic Phenotype by Noncontiguous Carcinogen-Transformed Epithelia Depends on the Transforming Carcinogen
por: Xu, Yuanyuan, et al.
Publicado: (2013)

Potentially carcinogenic analogues of the carcinogen hexamethylphosphoramide: evaluation in vitro.
por: Ashby, J., et al.
Publicado: (1978)

Selection of an in vitro carcinogenicity test for derivatives of the carcinogen hexamethylphosphoramide.
por: Ashby, J., et al.
Publicado: (1977)

On the Theory of Clonal Selection in Carcinogenic Transformation
por: Naha, P. M., et al.
Publicado: (1974)

Critical effective methods to detect genotoxic carcinogens and neoplasm-promoting agents.
por: Weisburger, J H, et al.
Publicado: (1991)

Urban air pollution by carcinogenic and genotoxic polyaromatic hydrocarbons in the former USSR.
por: Khesina AYa
Publicado: (1994)

The distinct health risk analyses required for genotoxic carcinogens and promoting agents.
por: Weisburger, J H, et al.
Publicado: (1983)

Role of prostaglandin-H synthase in mediating genotoxic and carcinogenic effects of estrogens.
por: Degen, G H
Publicado: (1990)

Non-genotoxic carcinogen exposure induces defined changes in the 5-hydroxymethylome
por: Thomson, John P, et al.
Publicado: (2012)

Genotoxic and Carcinogenic Effect of Gutkha: A Fast-growing Smokeless Tobacco
por: Sankhla, Bharat, et al.
Publicado: (2018)

MicotoXilico: An Interactive Database to Predict Mutagenicity, Genotoxicity, and Carcinogenicity of Mycotoxins
por: Tolosa, Josefa, et al.
Publicado: (2023)

Oxidative Stress in the Carcinogenicity of Chemical Carcinogens
por: Kakehashi, Anna, et al.
Publicado: (2013)

Integration of Epigenetic Mechanisms into Non-Genotoxic Carcinogenicity Hazard Assessment: Focus on DNA Methylation and Histone Modifications
por: Desaulniers, Daniel, et al.
Publicado: (2021)

Mammalian cell transformation in vitro. Six tests for carcinogenicity.
por: Styles, J. A.
Publicado: (1978)

Development of Korean CARcinogen EXposure: Assessment of the Exposure Intensity of Carcinogens by Industry
por: Koh, Dong-Hee, et al.
Publicado: (2022)

Summary of carcinogenic potency and positivity for 492 rodent carcinogens in the carcinogenic potency database.
por: Gold, L S, et al.
Publicado: (1989)

Development of Korean CARcinogen EXposure: An Initiative of the Occupational Carcinogen Surveillance System in Korea
por: Koh, Dong-Hee, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_uoqqncs4ur1mcjqnjdpk9id31e