High-Throughput Liquid Chromatography–Tandem Mass Spectrometry Quantification of Glycosaminoglycans as Biomarkers of Mucopolysaccharidosis II

We recently developed a blood–brain barrier (BBB)-penetrating enzyme transport vehicle (ETV) fused to the lysosomal enzyme iduronate 2-sulfatase (ETV:IDS) and demonstrated its ability to reduce glycosaminoglycan (GAG) accumulation in the brains of a mouse model of mucopolysaccharidosis (MPS) II. To...

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Detalles Bibliográficos
Autores principales: Wang, Junhua, Bhalla, Akhil, Ullman, Julie C., Fang, Meng, Ravi, Ritesh, Arguello, Annie, Thomsen, Elliot, Tsogtbaatar, Buyankhishig, Guo, Jing L., Skuja, Lukas L., Dugas, Jason C., Davis, Sonnet S., Poda, Suresh B., Gunasekaran, Kannan, Costanzo, Simona, Sweeney, Zachary K., Henry, Anastasia G., Harris, Jeffrey M., Henne, Kirk R., Astarita, Giuseppe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7432392/
https://www.ncbi.nlm.nih.gov/pubmed/32751752
http://dx.doi.org/10.3390/ijms21155449

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7432392/
https://www.ncbi.nlm.nih.gov/pubmed/32751752
http://dx.doi.org/10.3390/ijms21155449

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