Cargando…

Functional Alterations in the Olfactory Neuronal Circuit Occur before Hippocampal Plasticity Deficits in the P301S Mouse Model of Tauopathy: Implications for Early Diagnosis and Translational Research in Alzheimer’s Disease

Alzheimer’s disease (AD) is characterized by neuronal loss and impaired synaptic transmission, ultimately leading to cognitive deficits. Early in the disease, the olfactory track seems most sensitive to tauopathy, while most plasticity studies focused on the hippocampal circuits. Functional network...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ahnaou, Abdallah, Rodriguez-Manrique, Daniela, Biermans, Ria, Embrechts, Sofie, Manyakov, Nikolay V., Drinkenburg, Wilhelmus H.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7432464/ https://www.ncbi.nlm.nih.gov/pubmed/32751531 http://dx.doi.org/10.3390/ijms21155431

Ejemplares similares

NMDARs Containing NR2B Subunit Do Not Contribute to the LTP Form of Hippocampal Plasticity: In Vivo Pharmacological Evidence in Rats
por: Ahnaou, Abdallah, et al.
Publicado: (2021)

Aging Alters Olfactory Bulb Network Oscillations and Connectivity: Relevance for Aging-Related Neurodegeneration Studies
por: Ahnaou, A., et al.
Publicado: (2020)

Modulation of mGlu2 Receptors, but Not PDE10A Inhibition Normalizes Pharmacologically-Induced Deviance in Auditory Evoked Potentials and Oscillations in Conscious Rats
por: Ahnaou, Abdallah, et al.
Publicado: (2016)

In Vivo Plasticity at Hippocampal Schaffer Collateral-CA1 Synapses: Replicability of the LTP Response and Pharmacology in the Long-Evans Rat
por: Ahnaou, A., et al.
Publicado: (2020)

The phosphodiesterase-4 and glycine transporter-1 inhibitors enhance in vivo hippocampal theta network connectivity and synaptic plasticity, whereas D-serine does not
por: Ahnaou, A., et al.
Publicado: (2020)

Ketamine: differential neurophysiological dynamics in functional networks in the rat brain
por: Ahnaou, A, et al.
Publicado: (2017)

Functional Neurophysiological Biomarkers of Early-Stage Alzheimer’s Disease: A Perspective of Network Hyperexcitability in Disease Progression
por: Tok, Sean, et al.
Publicado: (2022)

Early Electrophysiological Disintegration of Hippocampal Neural Networks in a Novel Locus Coeruleus Tau-Seeding Mouse Model of Alzheimer's Disease
por: Ahnaou, A., et al.
Publicado: (2019)

Cholinergic Mechanisms of Target Oddball Stimuli Detection: The Late “P300-Like” Event-Related Potential in Rats
por: Ahnaou, A., et al.
Publicado: (2018)

p38 activation occurs mainly in microglia in the P301S Tauopathy mouse model
por: Perea, Juan R., et al.
Publicado: (2022)

mGlu2 Receptor Agonism, but Not Positive Allosteric Modulation, Elicits Rapid Tolerance towards Their Primary Efficacy on Sleep Measures in Rats
por: Ahnaou, Abdallah, et al.
Publicado: (2015)

Emergence of early alterations in network oscillations and functional connectivity in a tau seeding mouse model of Alzheimer’s disease pathology
por: Ahnaou, A., et al.
Publicado: (2017)

Dysfunction of the glutamatergic photoreceptor synapse in the P301S mouse model of tauopathy
por: Arouche-Delaperche, L., et al.
Publicado: (2023)

TFEB Overexpression in the P301S Model of Tauopathy Mitigates Increased PHF1 Levels and Lipofuscin Puncta and Rescues Memory Deficits12
por: Wang, Hongjie, et al.
Publicado: (2016)

Tauopathy-induced retinal dysfunction in the P301S mutant human tau transgenic mouse
por: Mazzaro, Nadia, et al.
Publicado: (2013)

Chronic Sleep Disruption Advances the Temporal Progression of Tauopathy in P301S Mutant Mice
por: Zhu, Yan, et al.
Publicado: (2018)

Organotypic Brain Slice Cultures of Adult Transgenic P301S Mice—A Model for Tauopathy Studies
por: Mewes, Agneta, et al.
Publicado: (2012)

SWI and phase imaging reveal intracranial calcifications in the P301L mouse model of human tauopathy
por: Ni, Ruiqing, et al.
Publicado: (2020)

Humanized APOE genotypes influence lifespan independently of tau aggregation in the P301S mouse model of tauopathy
por: Williams, Tristan, et al.
Publicado: (2023)

Glimepiride mitigates tauopathy and neuroinflammation in P301S transgenic mice: role of AKT/GSK3β signaling
por: Zaki, Mennatallah O., et al.
Publicado: (2022)

A Naturally Occurring Bovine Tauopathy Is Geographically Widespread in the UK
por: Jeffrey, Martin, et al.
Publicado: (2015)

Phospho-Tau Accumulation and Structural Alterations of the Golgi Apparatus of Cortical Pyramidal Neurons in the P301S Tauopathy Mouse Model
por: Antón-Fernández, Alejandro, et al.
Publicado: (2017)

Behavioural Functions and Cerebral Blood Flow in a P301S Tauopathy Mouse Model: A Time-Course Study
por: Ahmad, Faraz, et al.
Publicado: (2021)

Arterial spin labeling demonstrates preserved regional cerebral blood flow in the P301L mouse model of tauopathy
por: Kindler, Diana, et al.
Publicado: (2021)

P301S Mutant Human Tau Transgenic Mice Manifest Early Symptoms of Human Tauopathies with Dementia and Altered Sensorimotor Gating
por: Takeuchi, Hiroki, et al.
Publicado: (2011)

Altered Brain Arginine Metabolism and Polyamine System in a P301S Tauopathy Mouse Model: A Time-Course Study
por: Mein, Hannah, et al.
Publicado: (2022)

Pharmacological and pharmacokinetic properties of JNJ-40411813, a positive allosteric modulator of the mGlu2 receptor
por: Lavreysen, Hilde, et al.
Publicado: (2015)

Cortical high gamma network oscillations and connectivity: a translational index for antipsychotics to normalize aberrant neurophysiological activity
por: Ahnaou, A., et al.
Publicado: (2017)

Efficacy and Safety of A Liposome-Based Vaccine against Protein Tau, Assessed in Tau.P301L Mice That Model Tauopathy
por: Theunis, Clara, et al.
Publicado: (2013)

α-Lipoic acid improves abnormal behavior by mitigation of oxidative stress, inflammation, ferroptosis, and tauopathy in P301S Tau transgenic mice
por: Zhang, Yan-Hui, et al.
Publicado: (2017)

Structural MRI Reveals Cervical Spinal Cord Atrophy in the P301L Mouse Model of Tauopathy: Gender and Transgene-Dosing Effects
por: Sartoretti, Thomas, et al.
Publicado: (2022)

Effects of Low-Intensity Pulsed Ultrasound-Induced Blood–Brain Barrier Opening in P301S Mice Modeling Alzheimer’s Disease Tauopathies
por: Géraudie, Amandine, et al.
Publicado: (2023)

P62 accumulates through neuroanatomical circuits in response to tauopathy propagation
por: Blaudin de Thé, François-Xavier, et al.
Publicado: (2021)

Human P301L-Mutant Tau Expression in Mouse Entorhinal-Hippocampal Network Causes Tau Aggregation and Presynaptic Pathology but No Cognitive Deficits
por: Harris, Julie A., et al.
Publicado: (2012)

Neural oscillations during cognitive processes in an App knock-in mouse model of Alzheimer’s disease pathology
por: Jacob, Sofia, et al.
Publicado: (2019)

Mismatch negativity as EEG biomarker supporting CNS drug development: a transnosographic and translational study
por: Loiodice, Simon, et al.
Publicado: (2021)

Correction: Mismatch negativity as EEG biomarker supporting CNS drug development: a transnosographic and translational study
por: Loiodice, Simon, et al.
Publicado: (2021)

Diffusion Tensor Imaging Detects Acute Pathology-Specific Changes in the P301L Tauopathy Mouse Model Following Traumatic Brain Injury
por: Soni, Neha, et al.
Publicado: (2021)

Early Cognitive and Behavioral Deficits in Mouse Models for Tauopathy and Alzheimer’s Disease
por: Samaey, Celine, et al.
Publicado: (2019)

Epigenetic treatment of behavioral and physiological deficits in a tauopathy mouse model
por: Wang, Wei, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_ndsgmgdgr7mceqc8gdhk1utpmq