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The Association of Free Fatty Acids and Eicosanoids with the Severity of Depressive Symptoms in Stroke Patients
The study was designed to demonstrate the relationship of free fatty acids (FFAs) and eicosanoids levels with the severity of depressive symptoms in stroke. The ischemic stroke patients (n = 74) were included in the prospective study. The risk of depression was evaluated by the Beck Depression Inven...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7432477/ https://www.ncbi.nlm.nih.gov/pubmed/32717948 http://dx.doi.org/10.3390/ijms21155220 |
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author | Kotlega, Dariusz Zembron-Lacny, Agnieszka Golab-Janowska, Monika Nowacki, Przemyslaw Szczuko, Malgorzata |
author_facet | Kotlega, Dariusz Zembron-Lacny, Agnieszka Golab-Janowska, Monika Nowacki, Przemyslaw Szczuko, Malgorzata |
author_sort | Kotlega, Dariusz |
collection | PubMed |
description | The study was designed to demonstrate the relationship of free fatty acids (FFAs) and eicosanoids levels with the severity of depressive symptoms in stroke. The ischemic stroke patients (n = 74) were included in the prospective study. The risk of depression was evaluated by the Beck Depression Inventory-II (BDI-II) 7 days and 6 months after the stroke onset. FFAs and inflammatory metabolites were determined by gas chromatography and liquid chromatography. In the acute phase of stroke, BDI-II and FFAs inversely correlated with C13:0 tridecanoic acid, C15:1 cis-10-pentadecanoid acid, C17:1 cis-10- heptadecanoid acid, C18:0 stearic acid, C20:3n6 eicosatrienoic acid, C22:1cis13 docosenoic acid and C22:6n3 docosahexaenoic acid (DHA). DHA level was significantly lower in patients with low vs. high BDI-II score. In the follow-up examination, BDI-II score directly correlated with C16:0 palmitic acid. The changes in BDI-II score during 6-month observation inversely correlated with lipoxin A4 and protectin D1, and directly correlated with 5-oxo-ETE. Importantly, the severity of depressive symptoms was associated with n3 PUFA level. Diet-derived FFAs were observed to potentially affect the inflammatory pathways in pathogenesis of depression in stroke and reduced DHA levels can attenuate depressive symptoms in stroke patients. |
format | Online Article Text |
id | pubmed-7432477 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-74324772020-08-24 The Association of Free Fatty Acids and Eicosanoids with the Severity of Depressive Symptoms in Stroke Patients Kotlega, Dariusz Zembron-Lacny, Agnieszka Golab-Janowska, Monika Nowacki, Przemyslaw Szczuko, Malgorzata Int J Mol Sci Article The study was designed to demonstrate the relationship of free fatty acids (FFAs) and eicosanoids levels with the severity of depressive symptoms in stroke. The ischemic stroke patients (n = 74) were included in the prospective study. The risk of depression was evaluated by the Beck Depression Inventory-II (BDI-II) 7 days and 6 months after the stroke onset. FFAs and inflammatory metabolites were determined by gas chromatography and liquid chromatography. In the acute phase of stroke, BDI-II and FFAs inversely correlated with C13:0 tridecanoic acid, C15:1 cis-10-pentadecanoid acid, C17:1 cis-10- heptadecanoid acid, C18:0 stearic acid, C20:3n6 eicosatrienoic acid, C22:1cis13 docosenoic acid and C22:6n3 docosahexaenoic acid (DHA). DHA level was significantly lower in patients with low vs. high BDI-II score. In the follow-up examination, BDI-II score directly correlated with C16:0 palmitic acid. The changes in BDI-II score during 6-month observation inversely correlated with lipoxin A4 and protectin D1, and directly correlated with 5-oxo-ETE. Importantly, the severity of depressive symptoms was associated with n3 PUFA level. Diet-derived FFAs were observed to potentially affect the inflammatory pathways in pathogenesis of depression in stroke and reduced DHA levels can attenuate depressive symptoms in stroke patients. MDPI 2020-07-23 /pmc/articles/PMC7432477/ /pubmed/32717948 http://dx.doi.org/10.3390/ijms21155220 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Kotlega, Dariusz Zembron-Lacny, Agnieszka Golab-Janowska, Monika Nowacki, Przemyslaw Szczuko, Malgorzata The Association of Free Fatty Acids and Eicosanoids with the Severity of Depressive Symptoms in Stroke Patients |
title | The Association of Free Fatty Acids and Eicosanoids with the Severity of Depressive Symptoms in Stroke Patients |
title_full | The Association of Free Fatty Acids and Eicosanoids with the Severity of Depressive Symptoms in Stroke Patients |
title_fullStr | The Association of Free Fatty Acids and Eicosanoids with the Severity of Depressive Symptoms in Stroke Patients |
title_full_unstemmed | The Association of Free Fatty Acids and Eicosanoids with the Severity of Depressive Symptoms in Stroke Patients |
title_short | The Association of Free Fatty Acids and Eicosanoids with the Severity of Depressive Symptoms in Stroke Patients |
title_sort | association of free fatty acids and eicosanoids with the severity of depressive symptoms in stroke patients |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7432477/ https://www.ncbi.nlm.nih.gov/pubmed/32717948 http://dx.doi.org/10.3390/ijms21155220 |
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