Development of Androgen-Antagonistic Coumarinamides with a Unique Aromatic Folded Pharmacophore

First-generation nonsteroidal androgen receptor (AR) antagonists, such as flutamide (2a) and bicalutamide (3), are effective for most prostate cancer patients, but resistance often appears after several years due to the mutation of AR. Second-generation AR antagonists are effective against some of t...

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Detalles Bibliográficos
Autores principales: Koga, Hitomi, Negishi, Mai, Kinoshita, Marie, Fujii, Shinya, Mori, Shuichi, Ishigami-Yuasa, Mari, Kawachi, Emiko, Kagechika, Hiroyuki, Tanatani, Aya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7432827/
https://www.ncbi.nlm.nih.gov/pubmed/32759847
http://dx.doi.org/10.3390/ijms21155584

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7432827/
https://www.ncbi.nlm.nih.gov/pubmed/32759847
http://dx.doi.org/10.3390/ijms21155584

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