Mutation in Sodium-Glucose Cotransporter 2 Results in Down-Regulation of Amyloid Beta (A4) Precursor-Like Protein 1 in Young Age, Which May Lead to Poor Memory Retention in Old Age

Senescence-accelerated mouse prone 10 (SAMP10) exhibits cerebral atrophy and depression-like behavior. A line of SAMP10 with spontaneous mutation in the Slc5a2 gene encoding the sodium-glucose cotransporter (SGLT) 2 was named SAMP10/TaSlc-Slc5a2(slc) (SAMP10-ΔSglt2) and was identified as a renal dia...

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Detalles Bibliográficos
Autores principales: Unno, Keiko, Takagi, Yoshiichi, Konishi, Tomokazu, Suzuki, Mitsuhiro, Miyake, Akiyuki, Kurotaki, Takumi, Hase, Tadashi, Meguro, Shinichi, Shimada, Atsuyoshi, Hasegawa-Ishii, Sanae, Pervin, Monira, Taguchi, Kyoko, Nakamura, Yoriyuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7432872/
https://www.ncbi.nlm.nih.gov/pubmed/32759773
http://dx.doi.org/10.3390/ijms21155579

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7432872/
https://www.ncbi.nlm.nih.gov/pubmed/32759773
http://dx.doi.org/10.3390/ijms21155579

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