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Investigation of Strand-Selective Interaction of SNA-Modified siRNA with AGO2-MID
Small interfering RNA (siRNA) has been recognized as a powerful gene-silencing tool. For therapeutic application, chemical modification is often required to improve the properties of siRNA, including its nuclease resistance, activity, off-target effects, and tissue distribution. Careful siRNA guide...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
MDPI
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7432901/ https://www.ncbi.nlm.nih.gov/pubmed/32717920 http://dx.doi.org/10.3390/ijms21155218 |