Quantitative tests reveal that microtubules tune the healthy heart but underlie arrhythmias in pathology

Microtubule (MT) mechanotransduction links diastolic stretch to generation of NADPH oxidase 2 (NOX2)-dependent reactive oxygen species (ROS), signals we term X-ROS. While stretch-elicited X-ROS primes intracellular calcium (Ca(2+)) channels for synchronized activation in the healthy heart, the dysre...

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Detalles Bibliográficos
Autores principales: Joca, Humberto C., Coleman, Andrew K., Ward, Chris W., Williams, George S. B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7432954/
https://www.ncbi.nlm.nih.gov/pubmed/30582750
http://dx.doi.org/10.1113/JP277083

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7432954/
https://www.ncbi.nlm.nih.gov/pubmed/30582750
http://dx.doi.org/10.1113/JP277083

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