The NSD2/WHSC1/MMSET methyltransferase prevents cellular senescence‐associated epigenomic remodeling

Senescent cells may possess the intrinsic programs of metabolic and epigenomic remodeling, but the molecular mechanism remains to be clarified. Using an RNAi‐based screen of chromatin regulators, we found that knockdown of the NSD2/WHSC1/MMSET methyltransferase induced cellular senescence that augme...

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Detalles Bibliográficos
Autores principales: Tanaka, Hiroshi, Igata, Tomoka, Etoh, Kan, Koga, Tomoaki, Takebayashi, Shin‐ichiro, Nakao, Mitsuyoshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7433007/
https://www.ncbi.nlm.nih.gov/pubmed/32573059
http://dx.doi.org/10.1111/acel.13173

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7433007/
https://www.ncbi.nlm.nih.gov/pubmed/32573059
http://dx.doi.org/10.1111/acel.13173

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