Two-stage Bayesian hierarchical modeling for blinded and unblinded safety monitoring in randomized clinical trials

BACKGROUND: Monitoring and reporting of drug safety during a clinical trial is essential to its success. More recent attention to drug safety has encouraged statistical methods development for monitoring and detecting potential safety signals. This paper investigates the potential impact of the proc...

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Detalles Bibliográficos
Autores principales: Liu, Junhao, Wick, Jo, Martin, Renee’ H., Meinzer, Caitlyn, Roy, Dooti, Gajewski, Byron
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7433072/
https://www.ncbi.nlm.nih.gov/pubmed/32807102
http://dx.doi.org/10.1186/s12874-020-01097-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7433072/
https://www.ncbi.nlm.nih.gov/pubmed/32807102
http://dx.doi.org/10.1186/s12874-020-01097-6

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