GR and LSD1/KDM1A-Targeted Gene Activation Requires Selective H3K4me2 Demethylation at Enhancers

KDM1A-mediated H3K4 demethylation is a well-established mechanism underlying transcriptional gene repression, but its role in gene activation is less clear. Here, we report a critical function and mechanism of action of KDM1A in glucocorticoid receptor (GR)-mediated gene transcription. Biochemical p...

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Detalles Bibliográficos
Autores principales: Clark, Erin A., Wu, Feizhen, Chen, Yirui, Kang, Paco, Kaiser, Ursula B., Fang, Rui, Shi, Yujiang G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7433711/
https://www.ncbi.nlm.nih.gov/pubmed/31216473
http://dx.doi.org/10.1016/j.celrep.2019.05.062

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7433711/
https://www.ncbi.nlm.nih.gov/pubmed/31216473
http://dx.doi.org/10.1016/j.celrep.2019.05.062

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