Ribosome Recycling by ABCE1 Links Lysosomal Function and Iron Homeostasis to 3′ UTR-Directed Regulation and Nonsense-Mediated Decay

Nonsense-mediated decay (NMD) is a pathway that degrades mRNAs containing premature termination codons. Here we describe a genome-wide screen for NMD factors that uncovers an unexpected mechanism that broadly governs 3′ untranslated region (UTR)-directed regulation. The screen reveals that NMD requi...

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Detalles Bibliográficos
Autores principales: Zhu, Xiaoqiang, Zhang, He, Mendell, Joshua T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7433747/
https://www.ncbi.nlm.nih.gov/pubmed/32668236
http://dx.doi.org/10.1016/j.celrep.2020.107895

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7433747/
https://www.ncbi.nlm.nih.gov/pubmed/32668236
http://dx.doi.org/10.1016/j.celrep.2020.107895

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