Cargando…

Ribosome Recycling by ABCE1 Links Lysosomal Function and Iron Homeostasis to 3′ UTR-Directed Regulation and Nonsense-Mediated Decay

Nonsense-mediated decay (NMD) is a pathway that degrades mRNAs containing premature termination codons. Here we describe a genome-wide screen for NMD factors that uncovers an unexpected mechanism that broadly governs 3′ untranslated region (UTR)-directed regulation. The screen reveals that NMD requi...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhu, Xiaoqiang, Zhang, He, Mendell, Joshua T.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7433747/ https://www.ncbi.nlm.nih.gov/pubmed/32668236 http://dx.doi.org/10.1016/j.celrep.2020.107895

Ejemplares similares

Identification of elements in human long 3′ UTRs that inhibit nonsense-mediated decay
por: Toma, Kalodiah G., et al.
Publicado: (2015)

ABCE1 Controls Ribosome Recycling by an Asymmetric Dynamic Conformational Equilibrium
por: Gouridis, Giorgos, et al.
Publicado: (2019)

Ribosome recycling is coordinated by processive events in two asymmetric ATP sites of ABCE1
por: Nürenberg-Goloub, Elina, et al.
Publicado: (2018)

Both introns and long 3′-UTRs operate as cis-acting elements to trigger nonsense-mediated decay in plants
por: Kertész, Sándor, et al.
Publicado: (2006)

Long 3′-UTRs target wild-type mRNAs for nonsense-mediated mRNA decay in Saccharomyces cerevisiae
por: Kebaara, Bessie W., et al.
Publicado: (2009)

Chromatoid Body Protein TDRD6 Supports Long 3’ UTR Triggered Nonsense Mediated mRNA Decay
por: Fanourgakis, Grigorios, et al.
Publicado: (2016)

Molecular analysis of the ribosome recycling factor ABCE1 bound to the 30S post‐splitting complex
por: Nürenberg‐Goloub, Elina, et al.
Publicado: (2020)

CRISPR screening reveals a dependency on ribosome recycling for efficient SARS-CoV-2 programmed ribosomal frameshifting and viral replication
por: Rehfeld, Frederick, et al.
Publicado: (2023)

Multiple Transcripts from a 3′-UTR Reporter Vary in Sensitivity to Nonsense-Mediated mRNA Decay in Saccharomyces cerevisiae
por: Zaborske, John M., et al.
Publicado: (2013)

Alternative splicing and nonsense-mediated mRNA decay regulate mammalian ribosomal gene expression
por: Cuccurese, Monica, et al.
Publicado: (2005)

Features and factors that dictate if terminating ribosomes cause or counteract nonsense-mediated mRNA decay
por: Embree, Caleb M., et al.
Publicado: (2022)

Nonsense-mediated mRNA decay and metal ion homeostasis and detoxification in Saccharomyces cerevisiae
por: Zhang, Xinyi, et al.
Publicado: (2022)

Nonsense Suppression as an Approach to Treat Lysosomal Storage Diseases
por: Keeling, Kim M.
Publicado: (2016)

UPF2-Dependent Nonsense-Mediated mRNA Decay Pathway Is Essential for Spermatogenesis by Selectively Eliminating Longer 3'UTR Transcripts
por: Bao, Jianqiang, et al.
Publicado: (2016)

Spermatogenesis Studies Reveal a Distinct Nonsense-Mediated mRNA Decay (NMD) Mechanism for mRNAs with Long 3′UTRs
por: Mühlemann, Oliver
Publicado: (2016)

In Vivo Determination of Direct Targets of the Nonsense-Mediated Decay Pathway in Drosophila
por: Chapin, Alex, et al.
Publicado: (2014)

Antisense-oligonucleotide-directed inhibition of nonsense-mediated mRNA decay
por: Nomakuchi, Tomoki T., et al.
Publicado: (2015)

Readthrough of stop codons under limiting ABCE1 concentration involves frameshifting and inhibits nonsense-mediated mRNA decay
por: Annibaldis, Giuditta, et al.
Publicado: (2020)

Nonsense mRNA suppression via nonstop decay
por: Arribere, Joshua A, et al.
Publicado: (2018)

The ABC of Ribosome-Related Antibiotic Resistance
por: Wilson, Daniel N.
Publicado: (2016)

Yeast telomere maintenance is globally controlled by programmed ribosomal frameshifting and the nonsense-mediated mRNA decay pathway
por: Advani, Vivek M., et al.
Publicado: (2013)

Structural basis of trehalose recycling by the ABC transporter LpqY-SugABC
por: Liu, Fengjiang, et al.
Publicado: (2020)

Attenuation of Nonsense-Mediated mRNA Decay Enhances In Vivo Nonsense Suppression
por: Keeling, Kim M., et al.
Publicado: (2013)

Nonsense in the testis: multiple roles for nonsense-mediated decay revealed in male reproduction
por: MacDonald, Clinton C., et al.
Publicado: (2017)

No-nonsense: insights into the functional interplay of nonsense-mediated mRNA decay factors
por: Mailliot, Justine, et al.
Publicado: (2022)

Modulation of nonsense mediated decay by rapamycin
por: Martinez-Nunez, Rocio T., et al.
Publicado: (2017)

ICE1 promotes the link between splicing and nonsense-mediated mRNA decay
por: Baird, Thomas D, et al.
Publicado: (2018)

Physiological and pathological aspects of Aβ in iron homeostasis via 5'UTR in the APP mRNA and the therapeutic use of iron-chelators
por: Avramovich-Tirosh, Yael, et al.
Publicado: (2008)

Mechanism and regulation of the nonsense-mediated decay pathway
por: Hug, Nele, et al.
Publicado: (2016)

RNA virus evasion of nonsense-mediated decay
por: May, Jared P., et al.
Publicado: (2018)

Optimized protocol for quantifying 5′ UTR-mediated translation initiation in S. cerevisiae using direct analysis of ribosome targeting
por: Lewis, Cole J.T., et al.
Publicado: (2022)

Mechanisms and Regulation of Nonsense-Mediated mRNA Decay and Nonsense-Associated Altered Splicing in Lymphocytes
por: Lambert, Jean-Marie, et al.
Publicado: (2020)

Combining nonsense mutation suppression therapy with nonsense-mediated decay inhibition in neurofibromatosis type 1
por: Osum, Sara H., et al.
Publicado: (2023)

Hepcidin suppression and defective iron recycling account for dysregulation of iron homeostasis in heme oxygenase-1 deficiency
por: Kartikasari, Apriliana E R, et al.
Publicado: (2010)

Hepcidin suppression and defective iron recycling account for dysregulation of iron homeostasis in heme oxygenase-1 deficiency
por: Kartikasari, Apriliana E R, et al.
Publicado: (2009)

Lysosomal iron recycling in mouse macrophages is dependent upon both LcytB and Steap3 reductases
por: Meng, Fanjing, et al.
Publicado: (2022)

Dysfunction in nonsense-mediated decay, protein homeostasis, mitochondrial function, and brain connectivity in ALS-FUS mice with cognitive deficits
por: Ho, Wan Yun, et al.
Publicado: (2021)

Structure of the ribosome post-recycling complex probed by chemical cross-linking and mass spectrometry
por: Kiosze-Becker, Kristin, et al.
Publicado: (2016)

An unusual overrepresentation of genetic factors related to iron homeostasis in the genome of the fluorescent Pseudomonas sp. ABC1
por: Valenzuela‐Heredia, Daniel, et al.
Publicado: (2021)

Restoration of lysosomal function after damage is accompanied by recycling of lysosomal membrane proteins
por: Eriksson, Ida, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_526sv9tqpik96p8fnb1emut8bj