Altered MICOS Morphology and Mitochondrial Ion Homeostasis Contribute to Poly(GR) Toxicity Associated with C9-ALS/FTD

Amyotrophic lateral sclerosis (ALS) manifests pathological changes in motor neurons and various other cell types. Compared to motor neurons, the contribution of the other cell types to the ALS phenotypes is under-studied. G4C2 repeat expansion in C9ORF72 is the most common genetic cause of ALS along...

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Detalles Bibliográficos
Autores principales: Li, Shuangxi, Wu, Zhihao, Li, Yu, Tantray, Ishaq, De Stefani, Diego, Mattarei, Andrea, Krishnan, Gopinath, Gao, Fen-Biao, Vogel, Hannes, Lu, Bingwei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7433775/
https://www.ncbi.nlm.nih.gov/pubmed/32755582
http://dx.doi.org/10.1016/j.celrep.2020.107989

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7433775/
https://www.ncbi.nlm.nih.gov/pubmed/32755582
http://dx.doi.org/10.1016/j.celrep.2020.107989

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