Structures reveal gatekeeping of the mitochondrial Ca(2+) uniporter by MICU1-MICU2

The mitochondrial calcium uniporter is a Ca(2+)-gated ion channel complex that controls mitochondrial Ca(2+) entry and regulates cell metabolism. MCU and EMRE form the channel while Ca(2+)-dependent regulation is conferred by MICU1 and MICU2 through an enigmatic process. We present a cryo-EM structu...

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Detalles Bibliográficos
Autores principales: Wang, Chongyuan, Jacewicz, Agata, Delgado, Bryce D, Baradaran, Rozbeh, Long, Stephen Barstow
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2020
Materias:
Biochemistry and Chemical Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7434445/
https://www.ncbi.nlm.nih.gov/pubmed/32667285
http://dx.doi.org/10.7554/eLife.59991

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7434445/
https://www.ncbi.nlm.nih.gov/pubmed/32667285
http://dx.doi.org/10.7554/eLife.59991

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