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Structures reveal gatekeeping of the mitochondrial Ca(2+) uniporter by MICU1-MICU2
The mitochondrial calcium uniporter is a Ca(2+)-gated ion channel complex that controls mitochondrial Ca(2+) entry and regulates cell metabolism. MCU and EMRE form the channel while Ca(2+)-dependent regulation is conferred by MICU1 and MICU2 through an enigmatic process. We present a cryo-EM structu...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
eLife Sciences Publications, Ltd
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7434445/ https://www.ncbi.nlm.nih.gov/pubmed/32667285 http://dx.doi.org/10.7554/eLife.59991 |