Deficiency in the glycosyltransferase Gcnt1 increases susceptibility to tuberculosis through a mechanism involving neutrophils

Modulation of immunity and disease by glycans is increasingly recognized. However, how host glycosylation shapes and is shaped by tuberculosis remains poorly understood. We show that deficiency in the glucosaminyl (N-acetyl) transferase 1 (Gcnt1), a key enzyme for core-2 O-glycans biosynthesis, driv...

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Detalles Bibliográficos
Autores principales: Fonseca, Kaori L., Maceiras, Ana Raquel, Matos, Rita, Simoes-Costa, Luisa, Sousa, Jeremy, Cá, Baltazar, Barros, Leandro, Fernandes, Ana Isabel, Mereiter, Stefan, Reis, Ricardo, Gomes, Joana, Tapia, Gustavo, Rodríguez-Martínez, Paula, Martín-Céspedes, Montse, Vashakidze, Sergo, Gogishvili, Shota, Nikolaishvili, Keti, Appelberg, Rui, Gärtner, Fátima, Rodrigues, Pedro N. S., Vilaplana, Cristina, Reis, Celso A., Magalhães, Ana, Saraiva, Margarida
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7434595/
https://www.ncbi.nlm.nih.gov/pubmed/32203062
http://dx.doi.org/10.1038/s41385-020-0277-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7434595/
https://www.ncbi.nlm.nih.gov/pubmed/32203062
http://dx.doi.org/10.1038/s41385-020-0277-7

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