A Collision Coupling Model Governs the Activation of Neuronal GIRK1/2 Channels by Muscarinic-2 Receptors

The G protein-activated Inwardly Rectifying K(+)-channel (GIRK) modulates heart rate and neuronal excitability. Following G-Protein Coupled Receptor (GPCR)-mediated activation of heterotrimeric G proteins (Gαβγ), opening of the channel is obtained by direct binding of Gβγ subunits. Interestingly, GI...

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Detalles Bibliográficos
Autores principales: Berlin, Shai, Artzy, Etay, Handklo-Jamal, Reem, Kahanovitch, Uri, Parnas, Hanna, Dascal, Nathan, Yakubovich, Daniel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7435011/
https://www.ncbi.nlm.nih.gov/pubmed/32903404
http://dx.doi.org/10.3389/fphar.2020.01216

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7435011/
https://www.ncbi.nlm.nih.gov/pubmed/32903404
http://dx.doi.org/10.3389/fphar.2020.01216

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